Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production - PubMed
4 hours ago
- #Allergic Rhinitis
- #Tfh Cells
- #Systemic IgE
- Systemic allergen-specific IgE is crucial for allergic rhinitis symptoms.
- Systemic IgE facilitates Th2 cells' conversion to Tfh cells and local IgE production.
- Allergic rhinitis symptoms appear only when both systemic IgE and Th2 cells are present.
- Mast cell activation, through IgE or compound 48/80, triggers local IgE production.
- The study uses mouse models and single-cell RNA sequencing for insights.