Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway - PubMed
6 hours ago
- #Epigenetics
- #Telomeres
- #Cancer Biology
- Orphan nuclear receptors (COUP-TF1, COUP-TF2, TR2, TR4) recruit TRIM28 to promote H3K9me3 at telomeres for the Alternative Lengthening of Telomeres (ALT) pathway.
- ALT is a telomere maintenance mechanism used in embryonic stem cells and cancer cells, relying on high levels of telomeric H3K9me3.
- TRIM28 is required for orphan nuclear receptor-induced H3K9 methylation and ALT phenotypes; a TRIM28 variant defective in interaction fails to localize to telomeres or promote ALT.
- Physical interaction between orphan nuclear receptors and TRIM28 induces TRIM28's telomeric localization, linking chromatin structure to ALT activation.