The Controversial Issue of Hypervitaminosis B12 as Prognostic Factor of Mortality: Global Lessons from a Systematic Review and Meta-Analysis - PubMed
3 months ago
- #mortality
- #vitamin B12
- #meta-analysis
- Hypervitaminosis B12's role in all-cause mortality was investigated through a meta-analysis.
- 28 studies with 69,610 participants and 15,815 deaths were analyzed.
- High serum B12 levels slightly increased mortality risk in chronic diseases (RR = 1.40) and hospitalized patients (RR = 1.57).
- Meta-regression results were not statistically significant.
- Bayesian analysis supported risks but was limited by data availability.
- Findings suggest potential artefacts in linking high B12 to mortality.
- Conclusion: Hypervitaminosis B12 does not significantly increase all-cause mortality risk in adults.