Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects - PubMed
6 hours ago
- #exercise therapy
- #diabetic retinopathy
- #exerkines
- Exerkines are bioactive factors induced by exercise that may mediate retinal benefits in diabetic retinopathy (DR).
- The review highlights key exerkines like irisin, adiponectin, BDNF, FGF-21, apelin, and clusterin and their roles in DR-relevant pathways.
- Exerkines affect various retinal cell types including endothelial cells, pericytes, Müller glia, microglia, neurons, and the retinal pigment epithelium.
- The article distinguishes findings from retinal-specific models from extrapolated data and discusses exercise modality-specific exerkine signatures.
- Exerkines are presented as potential mediators, biomarkers, and therapeutic prospects alongside existing DR treatments like anti-VEGF therapy.