Multi-omic analysis of the liver-breast axis reveals key hepatic mediators of breast cancer progression - PubMed
7 hours ago
- #hepatic dysfunction
- #breast cancer
- #multi-omic analysis
- Hepatic dysfunction modulates breast cancer progression through metabolic, endocrine, and inflammatory crosstalk.
- Five key pathways identified: insulin resistance-driven IGF1-PI3K/AKT activation, estrogen metabolism imbalance, IL6-STAT3/NLRP3-mediated inflammation, HMOX1/APOE-dependent metabolic rewiring, and FAK-Src/MMP9-regulated ECM remodeling.
- Key molecular mediators include nuclear receptors (ESR1), cytokines (IL-1β), growth factors (HGF), and receptor tyrosine kinases.
- SPP1 and PTPN2 identified as potential circulating biomarkers linking hepatic dysfunction to aggressive breast cancer phenotypes.
- The study suggests potential therapeutic targets and emphasizes the need for translational validation and personalized strategies for breast cancer patients with liver conditions.