Macrophage-Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro - PubMed
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- #contact-dependent communication
- #wound healing signaling
- #macrophage-fibroblast crosstalk
- Macrophages promote fibroblast scratch closure in a contact-dependent manner that is independent of connexins.
- Fibroblasts regulate macrophage cytokine secretion: contact enhances IL10 production via Cx43 signaling, while paracrine interactions suppress TNFα secretion.
- Contact between fibroblasts and macrophages induces connexin-dependent intermittent calcium signals selectively in macrophages.
- ScRNA-seq shows that wounding reshapes macrophage and fibroblast populations and dynamically regulates cell adhesion molecules and intercellular signaling pathways.
- Contact-dependent calcium and connexin signaling integrates with transcriptional remodeling to coordinate macrophage-fibroblast behavior during healing.