Risk Prediction of Hepatocellular Carcinoma After Hepatitis B Surface Antigen Seroclearance in Patients With Chronic Hepatitis B - PubMed
6 hours ago
- #HBsAg Seroclearance
- #Risk Prediction
- #Hepatocellular Carcinoma
- Study focuses on predicting hepatocellular carcinoma (HCC) risk after HBsAg seroclearance in chronic hepatitis B (CHB) patients.
- Identified independent risk factors: age ≥50, male sex, cirrhosis, AVT-induced seroclearance, low platelets (≤150 × 10⁹/L), and low albumin (≤44 g/L).
- Developed a six-factor predictive model with good discrimination (Harrell's C-index: 0.766) and validated it internally.
- Model shows strong predictive ability for HCC at 3, 5, and 10 years (AUCs: 0.785, 0.775, 0.830).
- Aims to optimize surveillance strategies post-HBsAg seroclearance for better clinical outcomes.