Lactylation: a metabolic-epigenetic bridge in diabetic kidney disease and a therapeutic target for TCM - PubMed
4 days ago
- #Traditional Chinese medicine
- #Lactylation
- #Diabetic kidney disease
- Lactylation is an emerging epigenetic mechanism linking metabolic dysregulation to pathological gene expression in diabetic kidney disease (DKD).
- Lactacidosis exacerbates glomerular injury by promoting mesangial cell activation, podocyte damage, and disrupting mitochondrial function in tubules.
- Lactate accumulation and lactylation modulate immune cell function, intensifying inflammatory responses and activating pro-fibrotic pathways.
- Traditional Chinese medicine (TCM) compounds like Berberine, baicalin, ginsenoside compound K, and cordycepin show potential in reducing lactate production and modulating lactylation levels.
- TCM offers multi-targeted intervention strategies to suppress inflammatory and fibrotic responses in DKD.