Impacts of host genetics on gut microbiome composition in Alzheimer's disease - PubMed
3 days ago
- #Alzheimer's disease
- #Host genetics
- #Gut microbiome
- Host-microbiome interactions are crucial in Alzheimer's disease (AD) development.
- A study of 252 Chinese individuals linked gut microbiome composition to cognitive disability.
- Anaerostipes-enriched enterosignature (ES-Ana) was negatively associated with cognitive disability.
- 41 lead genetic variants were identified affecting ES-Ana relative abundance.
- High ES-Ana relative abundance correlated negatively with AD polygenic risk scores.
- 174 ES-Ana-associated genes were found, enriched in AD-related biological functions.
- These genes showed underexpression in glial cells during brain aging.
- The study highlights the gut-brain axis's role in AD.