Physical activity as a modifiable risk factor in preclinical Alzheimer's disease
6 months ago
- #Alzheimer's Disease
- #Physical Activity
- #Cognitive Decline
- Higher physical activity is associated with slower cognitive and functional decline in individuals with elevated baseline amyloid.
- The beneficial association of physical activity is not related to lower amyloid burden but to slower amyloid-related inferior temporal tau accumulation.
- A curvilinear relationship exists where the benefits of physical activity plateau at a moderate level (5,001–7,500 steps per day).
- Physical inactivity is a modifiable risk factor for Alzheimer’s disease (AD), with potential to modify disease trajectory during the preclinical period.
- The study supports targeting physical inactivity as an intervention in future AD prevention trials, especially in sedentary individuals with elevated amyloid.