Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML - PubMed
5 hours ago
- #AML
- #mitotic spindle
- #IL-23R
- Intracellular IL-23R has a novel role in AML, distinct from its classical surface expression on T cells.
- IL-23R levels are elevated in primary AML samples compared to normal hematopoietic cells.
- The receptor interacts with mitotic spindle proteins via its (S/T)x(I/L)P motif, influencing spindle formation.
- Depletion of IL-23R disrupts mitotic spindle assembly, reduces proliferation, and impairs stem/progenitor function in AML cells.
- Normal hematopoietic cells and progenitors are unaffected by IL-23R depletion, highlighting its AML-specific function.