OSBPL3-driven sterol metabolic reprogramming promotes oncogenic signaling and therapeutic resistance in pancreatic cancer - PubMed
3 days ago
- #Pancreatic Cancer
- #Therapeutic Resistance
- #OSBPL3
- OSBPL3 is highly expressed in pancreatic cancer (PDA) and associated with poor prognosis.
- Increased OSBPL3 expression enhances PDA cell proliferation, stemness, metastasis, and chemoresistance.
- OSBPL3 modulates PDA malignancy via the NOTCH signaling pathway.
- OSBPL3-driven sterol metabolic reprogramming enriches cholesterol esters and steroid metabolites.
- Inhibition of cholesterol synthesis enzymes reduces NOTCH pathway activity and stemness in PDA.
- Targeting OSBPL3 or its signaling could improve therapeutic efficacy in PDA patients.