Extracellular Vesicles from Bone Marrow Mesenchymal Stem Cells Modulate Proliferation, Migration, and Chemosensitivity in Ovarian Cancer Cells - PubMed
6 hours ago
- #ovarian-cancer
- #chemosensitivity
- #extracellular-vesicles
- Extracellular vesicles (EVs) from bone marrow mesenchymal stem cells (BM-MSCs) influence ovarian cancer cell behavior.
- BM-MSC-EVs increase cancer cell proliferation but reduce colony formation, migration, and invasion in vitro.
- EVs sensitize ALDH+ cancer stem-like cells to carboplatin but not paclitaxel.
- In vivo, EVs accelerate tumor growth and activate prosurvival, angiogenic, and epithelial-mesenchymal transition pathways.
- EVs are enriched in specific miRNAs (hsa-miR-100-5p, hsa-miR-122-5p, hsa-let-7i-5p) that may play a role in these effects.
- The study highlights the dual role of BM-MSC-EVs in both promoting tumor progression and enhancing carboplatin sensitivity.