Microbiome-Derived Indole-3-Lactic Acid Attenuates Cutibacterium Acnes-Induced Inflammation via the Aryl Hydrocarbon Receptor Pathway - PubMed
8 days ago
- #microbiome
- #aryl hydrocarbon receptor
- #acne vulgaris
- Microbiome-derived indole-3-lactic acid (ILA) shows potential as a novel therapeutic for acne vulgaris by attenuating Cutibacterium acnes-induced inflammation.
- ILA and indole-3-propionic acid (IPA) significantly reduce inflammatory mediators like TNF-α, IL-1β, and COX2 in C. acnes-stimulated keratinocytes.
- In vivo, ILA treatment reduces inflammatory cell infiltration, epidermal hyperplasia, and IL-1β expression in a C. acnes-induced acne mouse model.
- Transcriptomic analysis reveals ILA's mechanism involves downregulating inflammatory pathways (IL-17, TNF) and upregulating AHR-responsive genes (CYP1A1, CYP1B1).
- ILA-based topical formulations could serve as a non-antibiotic alternative for acne management, pending further clinical trials.