Electroacupuncture relieves joint pain by weakening the enhanced neuronal CXCR2-TRPA1 signaling in peripheral sensory neurons of a mouse model of acute gouty arthritis - PubMed
4 hours ago
- #Gouty Arthritis
- #Electroacupuncture
- #Pain Relief
- Electroacupuncture (EA) relieves joint pain in acute gouty arthritis (AGA) by modulating CXCR2-TRPA1 signaling in dorsal root ganglion (DRG) neurons.
- EA reduces CXCR2 overexpression in DRG neurons by decreasing STAT3 overactivation, weakening the enhanced neuronal CXCR2-TRPA1 coupling.
- Targeted knockdown of CXCR2 in DRG neurons mimics EA's effects, alleviating AGA symptoms.
- EA reduces downstream effects of CXCR2-TRPA1 signaling, including neuropeptide release (CGRP/substance P) and neutrophil infiltration in joints.
- Targeted overexpression of CXCR2 in DRG neurons negates EA's therapeutic benefits.
- The study supports EA as a viable treatment for AGA by providing mechanistic insights into its pain-relieving and anti-inflammatory effects.