Dissociation Between Metabolic Improvements and Mitochondrial Transcriptional Changes Following Exercise Training in Women with Polycystic Ovary Syndrome - PubMed
5 hours ago
- #PCOS
- #HIIT
- #metabolism
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder linked to insulin resistance in women of reproductive age.
- Regular physical activity, such as high-intensity interval training (HIIT), improves metabolic dysfunction in PCOS.
- A 12-week HIIT program in women with PCOS (n=8) reduced fasting glucose levels and improved whole-body insulin sensitivity (measured by glucose infusion rate, GIR).
- HIIT upregulated extracellular matrix (ECM)-related genes but did not affect mitochondrial-related gene expression in skeletal muscle (SM) or subcutaneous adipose tissue (SAT).
- Gene ontology analysis showed enrichment in pathways related to reduced oxidative stress and chronic inflammation.
- Metabolic improvements from exercise in PCOS may occur independently of mitochondrial gene expression changes.