Transcription factor Tono mediates histone H3K4 trimethylation to regulate endoreplication through transcriptional reprogramming - PubMed
3 hours ago
- #epigenetics
- #transcription factor
- #cell cycle
- Endoreplication is a cell cycle variant involving DNA replication without cell division, resulting in enlarged cells and organs.
- Study used Bombyx silk gland and Drosophila salivary gland to explore transcriptional reprogramming during the mitotic-to-endoreplication transition.
- Transcriptome profiling showed up-regulation of genes related to cell cycle control, growth, and morphogenesis after endoreplication entry.
- Global histone H3K4 trimethylation (H3K4me3) levels increased in silk gland post-endoreplication; Wds depletion blocks endoreplication.
- H3K4me3 targets and reprogrammes a subset of up-regulated genes.
- Transcription factor Tono recruits Wds-containing COMPASS complex to deposit H3K4me3 at target loci, promoting endoreplication.
- Findings reveal Tono-mediated epigenetic mechanism through H3K4me3 for transcriptional reprogramming to regulate endoreplication.