Glucocorticoids induce a phagocytic C1Q+ macrophage phenotype primed for IFNγ-dependent CXCL9 secretion - PubMed
2 hours ago
- #Immunotherapy
- #Tumor Microenvironment
- #Macrophage Polarization
- Glucocorticoids in the tumor microenvironment polarize macrophages into a C1Q+ CD163+ subtype with enhanced phagocytic activity.
- These glucocorticoid-induced macrophages, when stimulated by IFNγ, secrete higher levels of the T cell chemoattractant CXCL9 compared to classical M1 macrophages.
- In adrenocortical carcinoma (ACC) patients, high macrophage infiltration correlates with T cell recruitment, better immunotherapy response, and improved survival.