Dual role of LY96 in shaping the mesenchymal glioblastoma ecosystem through stem cell maintenance and macrophage MES-like reprogramming - PubMed
3 days ago
- #macrophage polarization
- #glioblastoma
- #LY96
- LY96 plays a dual role in mesenchymal glioblastoma (MES GBM) by maintaining stem cells and reprogramming macrophages.
- MES glioblastoma stem cells (GSCs) preferentially express and secrete LY96, activating NF-κB via an autocrine LY96-TNFRSF1B signaling axis.
- LY96 promotes GSC proliferation, self-renewal, and maintenance of the MES state.
- Inhibition of LY96 in vivo suppresses GBM growth and extends survival in animal models.
- LY96 also drives tumor-associated macrophages (TAMs) toward a MES-like state through paracrine signaling.
- Targeting LY96 and its downstream effectors could improve GBM treatment outcomes.