Hyperforin Attenuates Scopolamine Induced Alzheimer's Pathology in Rat Model: Abrogation of Caspase-1/11 Mediated Pyroptosis via Inhibition of HMGB1-Mediated RAGE Pathway - PubMed
5 hours ago
- #Alzheimer's disease
- #HMGB1/RAGE pathway
- #Neuroprotection
- Hyperforin (HPF) from St. John's wort shows neuroprotective effects in a scopolamine-induced Alzheimer's disease (AD) rat model.
- HPF suppresses the HMGB1/RAGE signaling pathway, reducing neuroinflammation and pyroptosis.
- The compound lowers levels of inflammatory cytokines (IL-1α, IL-1β, IL-18) and inhibits Aβ formation by downregulating BACE1.
- HPF blocks caspase-1/11 mediated pyroptosis, suggesting a potential therapeutic role in AD.
- The study highlights HPF's ability to mitigate neuronal damage and cognitive deficits in AD models.