Anti-Müllerian Hormone Levels Across Phenotypes in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis - PubMed
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- #Polycystic Ovary Syndrome
- #Meta-analysis
- #Anti-Müllerian Hormone
- Anti-Müllerian Hormone (AMH) levels are elevated in women with Polycystic Ovary Syndrome (PCOS), but clinical application is limited by lack of standardization.
- A systematic review and meta-analysis compared AMH levels across four PCOS phenotypes (A, B, C, D) defined by Rotterdam criteria.
- The study analyzed 49 studies (15,535 participants) from PubMed, Embase, ScienceDirect, and Web of Science (2009-2024).
- Highest AMH levels were found in phenotype A (11.49 ng/mL), followed by D (8.97), C (7.98), and B (6.25).
- Polycystic ovarian morphology had the greatest influence on AMH levels, followed by oligoanovulation and hyperandrogenism.
- The study highlights the need for AMH assay standardization and population-specific interpretation for phenotype differentiation.