Memory Regulatory T Cells as a Biomarker of Early Type I Diabetes - PubMed

5 hours ago

Type 1 diabetes (T1D) is a chronic autoimmune disease in children, caused by immune attack on pancreatic β-cells.
Memory regulatory T cells (memory Tregs) are significantly higher in T1D patients and their siblings compared to healthy controls.
Memory Tregs correlate with disease status and age, but not in T1D patients where age does not affect levels.
Siblings of T1D patients show intermediate memory Treg levels, overlapping with both T1D patients and healthy controls.
Memory Tregs could serve as a minimally invasive biomarker for early T1D diagnosis and personalized immunotherapy.
Diabetic ketoacidosis does not influence immune cell populations in T1D patients.

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