Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance - PubMed
11 hours ago
- #immunotherapy
- #cancer
- #glucocorticoids
- Glucocorticoids (GCs) suppress anticancer immune responses, with ACBP/DBI identified as a key mediator.
- Corticosterone (CORT) accelerates tumor progression and reduces efficacy of immunogenic chemotherapy and PD-1 blockade in mouse models.
- Neutralizing ACBP/DBI via genetic ablation or monoclonal antibodies restores antitumor immunity in a T cell-dependent manner.
- CORT induces Tsc22d3 in dendritic cells, impairing type I interferon signaling and antigen presentation, reversible by ACBP/DBI neutralization.
- ACBP/DBI neutralization emerges as a potential therapeutic strategy to counteract GC-induced immune suppression in cancer.