Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis - PubMed
5 hours ago
- #FAK signaling
- #eIF6
- #SCLC
- Eukaryote initiation factor 6 (eIF6) regulates non-neuroendocrine (non-NE) transdifferentiation in small-cell lung carcinoma (SCLC).
- eIF6 expression is upregulated in non-NE states across cell lines, mouse models, and patient samples, leading to global translational landscape remodeling.
- Mechanistically, eIF6 interacts with the CD104-FAK complex, activating the MAPK pathway.
- Targeting eIF6 suppresses non-NE transdifferentiation and enhances chemotherapy sensitivity in SCLC.
- The eIF6-CD104-FAK axis is proposed as a prognostic marker and therapeutic target to combat SCLC resistance.