Identification of ALDH1A2-mediated cardioprotective benefits in myocardial ischaemia-reperfusion injury - PubMed
7 days ago
- #Retinoic Acid
- #ALDH1A2
- #Myocardial Ischaemia-Reperfusion Injury
- ALDH1A2 plays a central role in protecting against myocardial ischaemia-reperfusion (MIR) injury.
- Retinoic acid (RA) signaling, activated post-myocardial infarction, aids in cardiac repair.
- Aldh1a2 ablation worsens heart dysfunction, while its overexpression provides protection against I/R injury.
- ALDH1A2's cardioprotective effect is largely due to its role in catalyzing RA production.
- RA produced by cardiomyocytes inhibits cell death and fibrosis by regulating Bmp7 transcription.
- Enhancing Aldh1a2 transcription and RA signaling could be a potential treatment for MIR injury.