Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials - PubMed
5 hours ago
- #peripheral vascular disease
- #cardiovascular risk
- #aortic calcification
- Aortic and iliac calcifications are investigated as predictors for aortic dissection, aneurysm rupture, and peripheral vascular disease.
- The study included 13,065 participants (94% men, mean age 67±4 years) from the DANCAVAS trials with thoracoabdominal aortic CT scans.
- Calcification was measured in a 5-segment model and categorized into quartiles, except for the ascending aorta, which had 4 exposure groups.
- Participants were followed for a mean of 8 years, with 42 aortic events and 311 major adverse limb events (MALEs) recorded.
- Severe calcification in the ascending and abdominal aorta significantly increased the risk of aortic events (SHR 3.06 and 7.61, respectively).
- Calcification in all segments (ascending aorta, aortic arch, descending aorta, abdominal aorta, iliac arteries) was strongly associated with MALEs.
- The highest risk for MALEs was seen in the iliac arteries (SHR 13.52).
- The study concludes that severe aortic and iliac calcification significantly increases the risk of aortic events and MALEs, aiding in risk stratification.