First Total-Body Kinetics Study of 18F-Flurpiridaz in Healthy Volunteers at Rest and Feasibility of Simplified Quantitative Strategies - PubMed
6 hours ago
- #18F-flurpiridaz
- #total-body PET
- #pharmacokinetics
- First total-body kinetics study of 18F-flurpiridaz in 12 healthy volunteers at rest using a 60-min dynamic PET/CT scan.
- Four distinct kinetic patterns observed across different organs; 2T4K model superior for most regions at 60 min.
- Logan VT from 30-min and 60-min scans strongly correlates with reference VT, supporting shortened acquisition protocols.
- SUVmean around 10-min postinjection also shows strong correlation, indicating feasibility of ultrashort imaging strategies.
- Findings establish foundation for clinical applications in oncology, neurology, and integrated cardio-oncology diagnostics.