Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis - PubMed
5 hours ago
- #juvenile idiopathic arthritis
- #biomarkers
- #neuroinflammation
- Children with systemic juvenile idiopathic arthritis (sJIA) show increased rates of emotional and behavioral symptoms, with unclear underlying biological mechanisms.
- Plasma samples from active sJIA patients revealed altered neurobiological protein profiles, correlating with pain and life impact scores, persisting even during inactive disease phases.
- Chronic arthritic mice displayed hippocampal microglial activation and impaired neurogenesis, with RNA-seq analysis linking mitochondrial dysfunction and oxidative stress to neuroinflammation.
- Haem oxygenase 2 (HMOX2) was identified as a peripheral biomarker for hippocampal microglial activation, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are implicated as potential drivers of this process in sJIA.