Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets - PubMed
3 months ago
- #Rejuvenation
- #Epigenetics
- #Aging
- Rejuvenation in aging mice can be achieved through long-term partial reprogramming using factors like Oct4, Sox2, Klf4, and c-Myc.
- DNA methylation changes in skin from partially reprogrammed, young, and old mice were analyzed using whole-genome bisulfite sequencing.
- Aging and rejuvenation-related epigenetic changes converge on Polycomb repressive complex 2 (PRC2) targets, showing increased DNA methylation and entropy.
- Aged epidermis shows extensive loss of H3K27me3, overlapping with regions affected by age- and rejuvenation-related DNA methylation changes.
- Large H3K9me2-marked 'LOCK' heterochromatin domains define boundaries for hypomethylated, highly entropic regions during aging.
- PRC2 targets are prominently enriched in gene expression data, suggesting PRC2 activity modulates aging and mediates rejuvenation.