Xist RNA dependent and independent mechanisms regulate dynamic X chromosome inactivation in B lymphocytes - PubMed
5 hours ago
- #B lymphocytes
- #X chromosome inactivation
- #epigenetic regulation
- X chromosome inactivation (XCI) is dynamic in female B lymphocytes, with heterochromatic marks varying by cell state.
- Naive B cells show depletion of H2AK119Ub and H3K9me3 on the inactive X chromosome but enrichment of DNA methylation and H3K27me3.
- H3K27me3 maintains an Xist RNA-dependent memory of XCI in naive B cells.
- Upon stimulation, Xist-independent H3K27me3 and Xist-dependent H2AK119Ub modifications accumulate on the inactive X chromosome.
- The findings highlight the role of Xist RNA, H3K27me3, and H2AK119Ub marks in regulating XCI following B cell activation.