Molecular insights into glial neuroimmune cross reactivity with CNS antigens and its role in neuroinflammation - PubMed
3 days ago
- #Blood-Brain Barrier
- #Glial Activation
- #Neuroinflammation
- Neuroinflammation is a key player in neurodegenerative and psychiatric disorders.
- Glial-neuroimmune interactions involve cytokine signaling, glial activation, and BBB modulation.
- Microglia M1/M2 polarization and astrocyte reactivity are common in neurotoxicity and chronic inflammation.
- Cytokines like TNF-α, IL-1β, and IL-6 disrupt the BBB, allowing peripheral immune cell infiltration.
- NLRP3 inflammasome and mitochondrial dysfunction enhance neuroimmune signaling.
- Shared glia-cytokines-BBB relationships are observed across disease models like MS, Alzheimer's, and Parkinson's.
- Advanced in vitro systems (e.g., organ-on-a-chip, brain organoids) aid in modeling and drug screening.
- Potential therapeutic targets include molecular interactions in glia-neuroimmune cross-reactivity.
- Integrative systems and AI-driven strategies could accelerate clinical translation in neuroinflammation.