What new renal biomarkers tell us about renal physiology: Collection: physiology applied to ICU - PubMed
5 days ago
- #kidney physiology
- #renal biomarkers
- #acute kidney injury
- The kidney maintains internal homeostasis through waste elimination, electrolyte and acid-base regulation, and endocrine functions.
- Novel renal biomarkers provide detailed insights into renal function and injury beyond traditional measures like serum creatinine and urine output.
- Cystatin C and proenkephalin serve as more reliable indicators of glomerular filtration rate (GFR), unaffected by muscle mass.
- TIMP-2 and IGFBP7 reveal early cellular stress responses, indicating G1 cell cycle arrest in tubular epithelial cells.
- NGAL and related molecules provide information on tubular damage and acute damage responses.
- Chemokines like CCL14 and CXCL9 highlight immune-mediated aspects of renal physiology and tissue repair.
- Urine microscopy offers insights into tubular cell health.
- Multiparametric MRI (mpMRI) enables non-invasive evaluation of renal perfusion, oxygenation, and fibrosis.
- These biomarkers distinguish between functional changes, cellular stress responses, and structural injury.
- They enhance understanding of renal pathophysiology, identify specific AKI types, and stratify patients for interventions.