A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical niches - PubMed
3 days ago
- #spatial atlas
- #glioblastoma
- #cellular organization
- A spatially resolved atlas of human glioblastoma integrates gene expression, single-cell, and protein data to reveal cellular and molecular patterns.
- Identifies less-characterized cell states (endothelial, perivascular, fibroblast-like) and their spatial associations with malignant and immune compartments.
- Highlights a distinct oligodendrocyte population in tumor core and perivascular regions linked to recurrence and poor clinical outcomes.
- Provides a high-resolution framework for studying glioblastoma organization and potential therapeutic vulnerabilities.
- The atlas is publicly accessible, aiding further research into glioblastoma's spatial and cellular complexity.