SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration - PubMed
5 hours ago
- #IVDD
- #SOD1 lactylation
- #ZL-01
- Lactate accumulation is a hallmark of intervertebral disc degeneration (IVDD).
- SOD1 lactylation at lysine 123 (SOD1K123la) is identified as crucial for IVDD aggravation.
- SOD1K123la alters SOD1 conformation, impairs its enzymatic activity, and induces oxidative damage.
- SOD1K123la activates the p53 pathway in nucleus pulposus cells (NPCs).
- A small molecule ZL-01 inhibits SOD1K123la and alleviates IVDD in male rats.
- NPC-targeted delivery of ZL-01 via collagen type II-targeted peptide-modified extracellular vesicles shows therapeutic potential.