Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death - PubMed
2 hours ago
- #iron metabolism
- #colorectal cancer
- #oxidative stress
- Colorectal cancer cells are addicted to iron, which promotes their growth and proliferation.
- Despite iron's cytotoxicity, these cells resist iron-induced oxidative death via a heme-SDH-CoQ axis.
- Heme-dependent SDH reduces CoQ, which acts as a antioxidant to detoxify lipid ROS.
- This metabolic adaptation allows CRC cells to survive under high iron conditions, revealing potential therapeutic targets.