Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3 - PubMed
10 hours ago
- #Ferroptosis
- #Vitamin A
- #ACSL3
- Vitamin A and its metabolite all-trans retinoic acid act as potent ferroptosis inhibitors, independent of antioxidant mechanisms or RAR/RXR signaling.
- These compounds directly target ACSL3, enhancing its activity to increase the MUFA/PUFA ratio in phospholipids and prevent lipid peroxidation.
- Vitamin A analogues alleviate ferroptosis-associated pathologies in mice and extend lifespan in C. elegans via ACSL3-dependent mechanisms.
- The findings reveal a new role for Vitamin A in modulating lipid metabolism, with implications for treating ferroptosis-related diseases and aging.