Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies - PubMed

4 hours ago

Fibrosis is a maladaptive process with excessive extracellular matrix deposition due to dysregulated tissue repair.
It affects multiple organs (e.g., lung, heart, liver, kidney), leading to architectural distortion, organ failure, and increased mortality.
Multiomics technologies reveal fibrosis as a dynamic alteration across molecular, cellular, microenvironmental, and organ levels.
A translational gap exists between identifying antifibrotic targets and developing effective human therapies.
The review covers milestones in fibrosis research, organ-specific mechanisms, and cellular changes in key players like parenchymal cells, fibroblasts, endothelial cells, and immune cells.
Key signaling pathways in fibrosis pathogenesis are outlined, along with clinical trials and future research directions like multiomics integration, CAR-T therapy, and AI applications.

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