USP30 alleviates intestinal ischemia-reperfusion injury by deubiquitinating MFN2 mediating the mitochondrial endoplasmic reticulum pathway - PubMed
6 hours ago
- #Ischemia-Reperfusion Injury
- #USP30
- #MFN2
- USP30 alleviates intestinal ischemia-reperfusion (IIR) injury by deubiquitinating MFN2.
- IIR injury causes intestinal barrier damage, systemic inflammation, and high mortality due to mitochondrial-endoplasmic reticulum network disorder.
- USP30, located on the mitochondrial outer membrane, reverses ubiquitination of Parkin substrates to maintain mitochondrial function.
- MFN2, a mitochondrial outer membrane fusion protein, mediates mitophagy, endoplasmic reticulum stress, and MAMs formation.
- Overexpression of USP30 increases MFN2 stability via deubiquitination, restoring mitochondrial dysfunction and endoplasmic reticulum stress caused by IIR.
- Knockdown of MFN2 weakens USP30's protective effect on MAMs.
- USP30's regulation of MFN2 ubiquitination is a potential therapeutic strategy for IIR injury.