Exosomal THBS4 Derived From Human Placental Mesenchymal Stem Cells Promotes the Migration and Angiogenesis of the Endothelial Cells in Preeclampsia by Activating the Integrin α2/PI3K/AKT Axis - PubMed
5 hours ago
- #preeclampsia
- #exosomes
- #angiogenesis
- Exosomal THBS4 from human placental mesenchymal stem cells (hPMSCs) promotes endothelial cell migration and angiogenesis in preeclampsia (PE).
- THBS4 activates the Integrin α2/PI3K/AKT signaling pathway, enhancing endothelial function.
- PMSC-derived exosomes (PMSC-Exos) alleviate PE symptoms in a rat model, improving placental structure and fetal growth.
- THBS4 expression is downregulated in preeclamptic placental tissues compared to healthy ones.
- PMSC-Exos offer a cell-free therapeutic alternative for PE, with THBS4 as a potential key therapeutic target.