PRC2.1 Coordinates Peri-Nucleolar H3K27me3-Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity - PubMed
4 hours ago
- #PRC2.1
- #phase separation
- #nucleolus
- PRC2.1, including the PCL2 subunit, associates with H3K27me3-enriched heterochromatin to form a ring-like structure around the nucleolus.
- PCL2 undergoes phase separation, and its intrinsically disordered region (IDR) regulates condensate fluidity and interaction with nucleolar protein NPM1.
- PCL2 facilitates NPM1 pentamerization and interactions among nucleolar components, promoting efficient rRNA synthesis and protein production.
- PRC2.1(PCL2) is crucial for maintaining nucleolar integrity and is required for cell proliferation.