Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis - PubMed
4 hours ago
- #Organelle Dynamics
- #Light-Based Modulation
- #Astrocyte Calcium Signaling
- Developed a tunable light-based tool to modulate astrocytic Ca2+ activity, mimicking endogenous signaling patterns.
- Found that local Ca2+ spikes enhance organelle entry into processes, while global Ca2+ waves arrest organelle movement.
- Showed that global Ca2+ elevations suppress motor-driven transport when bypassing cargo adaptors via FKBP-FRB assays.
- Demonstrated that Ca2+-dependent distal organelle accumulation promotes astrocyte process elongation and structural remodeling.
- The method provides a versatile platform for eliciting endogenous-like Ca2+ patterns and decoding their physiological roles in astrocytes.