ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA - PubMed
5 hours ago
- #RNA
- #virology
- #ubiquitin
- ZNFX1 is an RNA helicase with bifurcating E3 ubiquitin ligase activity.
- It uses a two-component ubiquitin circuit to generate K63-linked and K48-linked polyubiquitin chains.
- K63-linked chains facilitate RNA entrapment in ZNFX1 aggregates, restricting viral replication.
- K48-linked chains promote ZNFX1 turnover.
- Pathogenic ZNFX1 variants are defective in viral restriction, linking RNA entrapment to antiviral immunity.
- Mutations in ZNFX1 cause severe pediatric immunodeficiencies.