Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases - PubMed
12 hours ago
- #cell-free DNA
- #machine learning
- #liver cirrhosis
- Cell-free DNA (cfDNA) fragmentomes can be used for noninvasive detection of liver cirrhosis and other diseases.
- A machine learning classifier was developed to detect early liver disease, advanced fibrosis, and cirrhosis with high sensitivity.
- The study involved 1576 individuals, including those with liver disease and other morbidities like vascular, autoimmune, and neurodegenerative conditions.
- Genome-wide fragmentome and methylome analyses revealed liver-derived and immune-mediated changes in cfDNA in individuals with liver disease.
- Fragmentomic changes were observed across various human morbidities, reflecting disease-specific changes in circulation.
- A machine learning model using cfDNA fragmentomes predicted overall survival in separate morbidity cohorts.
- The study demonstrates the connection between cfDNA fragmentomes and an individual's physiologic state, offering new possibilities for cfDNA liquid biopsies.