SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia - PubMed
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- #acute myeloid leukemia
- #MECOM
- #SPINK2
- SPINK2 silencing suppresses leukemic proliferation in acute myeloid leukemia (AML).
- Restores myeloid commitment via MECOM downregulation, particularly in complex karyotype AML.
- SPINK2 is associated with cell cycle regulators, especially S-phase genes.
- shRNA-mediated SPINK2 silencing in AML cell lines impairs proliferation and induces myeloid differentiation.
- SPINK2 deficiency shows a significant link with MECOM expression in complex karyotype AML.
- Potential therapeutic target for complex karyotype AML patients with poor prognosis.