Metabolic pathway analysis reveals hierarchical pentose sugar utilization and metabolic flexibility of Bifidobacterium longum - PubMed
6 hours ago
- #Bifidobacterium
- #gut microbiota
- #pentose metabolism
- Metabolic pathway analysis of Bifidobacterium longum subsp. longum reveals hierarchical pentose sugar utilization.
- Arabinose, xylose, and ribose share a common ABC-type uptake system encoded by penABCD.
- Arabinose and xylose are converted into xylulose-5-phosphate via araBDA gene cluster and xylA/xylB genes, respectively.
- Ribose is converted into ribose-5-phosphate by rbsK.
- These intermediates enter the bifid shunt, an energy-generating fermentative pathway.
- Arabinose and xylose are co-metabolized, with xylose preferred over ribose.
- Multi-omics approach (genomics, transcriptomics, mutational analysis) provides molecular insights into pentose metabolism.