Wnt5a-Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF-κB Pathway - PubMed
6 hours ago
- #Exosomes
- #Neuroinflammation
- #Spinal Cord Injury
- The study investigated how Wnt5a-induced exosomes from bone marrow mesenchymal stem cells (BMSCs) support spinal cord injury repair.
- Wnt5a-enriched exosomes enhanced neural stem cell proliferation and neuronal differentiation while reducing astrocyte formation.
- High-throughput sequencing linked Wnt5a to the NF-κB pathway, with experiments showing Wnt5a suppresses this pathway.
- In vivo, Wnt5a-modified exosomes promoted microglia polarization to an anti-inflammatory M2 phenotype and improved tissue structure and motor function.
- Wnt5a enhances the regenerative effects of BMSC-Exos by modulating immune responses and inhibiting neuroinflammation via NF-κB.