Hallmarks of liver cancer: Therapeutic implications - PubMed
5 hours ago
- #liver cancer
- #therapeutic implications
- #hallmarks of cancer
- The hallmarks of cancer framework, first proposed in 2000, has reshaped liver cancer care, influencing therapeutic strategies.
- Primary liver cancers include hepatocellular carcinoma (HCC, 85%) and intrahepatic cholangiocarcinoma (iCCA, 10%), both with high mortality.
- HCC key hallmarks involve sustaining proliferative signaling, inducing vasculature, and avoiding immune detection, with immunotherapies improving outcomes in advanced cases.
- iCCA is characterized by hallmarks like sustained proliferative signaling, deregulated cellular metabolism, and immune avoidance, and about 45% have targetable alterations such as FGFR2 fusions and IDH1 mutations.
- Breakthroughs in management include precision oncology approaches for iCCA and ongoing efforts to enhance therapeutic strategies based on the hallmarks framework.