Temporal dynamics in cancer immunotherapy: the interplay between circadian rhythms, tumor microenvironment, and immune checkpoint blockade - PubMed
6 hours ago
- #Tumor Microenvironment
- #Cancer Immunotherapy
- #Circadian Rhythms
- The tumor microenvironment (TME) is a dynamic system influencing tumor progression and therapy response.
- Circadian rhythms interact with TME, affecting immune checkpoint inhibitor (ICI) efficacy.
- Circadian rhythms regulate tumor cell traits, immune cell function, angiogenesis, and fibroblast activity.
- TME impacts ICI efficacy through immunosuppression, immune checkpoint expression, T cell states, and drug bioavailability.
- Optimization strategies for ICI include circadian-based dosing, TME-targeted combos, rhythm modulation, and personalized approaches.
- Future research focuses on multi-omics, AI-driven chronomedicine, novel therapies, and clinical translation systems.