Pleiotropic effects of renal denervation beyond blood pressure reduction - PubMed
4 hours ago
- #Renal Denervation
- #Sympathetic Nervous System
- #Pleiotropic Effects
- Renal denervation (RDN) reduces blood pressure by decreasing sympathetic nervous system (SNS) overactivation, which is implicated in hypertension and other conditions.
- Preclinical and clinical studies suggest RDN may have protective effects on kidneys, improve heart failure outcomes, reduce atrial fibrillation burden, modestly benefit glucose metabolism, and lessen obstructive sleep apnea severity.
- Further large-scale trials are needed to confirm these pleiotropic effects, clarify their clinical significance, and determine their relationship to blood pressure changes induced by RDN.