The association between immune cells and acute kidney injury: insights from Mendelian randomization - PubMed
5 hours ago
- #acute kidney injury
- #immune cells
- #Mendelian randomization
- Study investigates the association between 731 immune cell phenotypes and acute kidney injury (AKI) using Mendelian randomization.
- Data on immune cell phenotypes were sourced from GWAS Catalog and Open GWAS databases, while AKI-related outcomes came from Finngen R11 and CKDGen databases.
- Nine immune phenotypes were significantly associated with acute renal failure (ARF), and four were linked to rapid kidney function decline.
- Sensitivity analyses, including leave-one-out and other MR models, confirmed the robustness of the findings.
- The study provides genetic evidence of a causal relationship between specific immune cells and AKI, offering insights for future clinical research.